Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response
| Autor: | Toshitaka Nabeshima, Tsutomu Kameyama, Keiko Tohyama |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Physostigmine Azides medicine.drug_class Scopolamine Hippocampus Mice Inbred Strains Pharmacology Neurotransmission Chlordiazepoxide Choline Benzodiazepines Mice Reference Values medicine Avoidance Learning Inverse agonist Animals Cerebral Cortex Benzodiazepine General Neuroscience Affinity Labels Acetylcholine carbohydrates (lipids) Kinetics medicine.anatomical_structure Cerebral cortex Anesthesia lipids (amino acids peptides and proteins) Psychology medicine.drug |
| Zdroj: | Neuroscience letters. 117(1-2) |
| ISSN: | 0304-3940 |
| Popis: | The chlordiazepoxide (CDP)-induced impairment of the passive avoidance response was attenuated by Ro 15-4513, a benzodiazepine inverse agonist, physostigmine and scopolamine at low doses. In a biochemical approach, CDP increased, but Ro 15-4513 decreased the acetylcholine (ACh) levels of cerebral cortex. After the training of passive avoidance, the ACh levels in the hippocampus and cerebral cortex decreased. This change disappeared by pretraining administration of CDP. These results suggest that the effect of CDP on the passive avoidance response was related to AChergic neuronal systems. |
| Databáze: | OpenAIRE |
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