Association between increased FVIIa-antithrombin complex/FVIIa ratio and pre-eclampsia
| Autor: | Luca Spiezia, Barry Woodhams, Erich Cosmi, Claudia M. Radu, Silvia Visentin, Maria Bon, Paolo Simioni |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Factor VIIa Normal pregnancy Antithrombins Tissue factor Young Adult Pre-Eclampsia Pregnancy medicine Humans Young adult Gynecology Eclampsia business.industry Antithrombin Case-control study Obstetrics and Gynecology Plasma levels medicine.disease Case-Control Studies Multiprotein Complexes Pediatrics Perinatology and Child Health Female Pregnancy Trimesters business medicine.drug |
| Popis: | Activated factor VII-antithrombin (FVIIa-AT) complexes can be used to reflect the degree of intravascular exposure of tissue factor (TF). The aim of the present case-control study was to evaluate FVIIa-AT plasma levels during normal pregnancy and in pre-eclampsia (PE).One hundred and five pregnant women were enrolled and namely n = 30 in the first (T1), n = 30 in the second (T2), n = 30 in the third (T3) trimester of pregnancy and n = 15 with PE. FVIIa-AT complexes were determined using a specific ELISA (Diagnostica Stago, Asnieres, France).FVIIa-AT complexes were significantly higher in pregnant (119 ± 24 pM) than in healthy (102 ± 12 pM, p = 0.001) women. No difference in FVIIa-AT levels between T3 women and with PE was observed. Interestingly, women with PE had significantly higher FVIIa-AT/FVIIa ratio than women during T3 (2.01 ± 0.44 versus 1.50 ± 0.29, p = 0.001).FVIIa-AT complexes plasma levels differed significantly between normal pregnancy and non-pregnant women. Moreover, FVIIa-AT/FVIIa ratio was higher in patients with PE than in normal pregnant women. |
| Databáze: | OpenAIRE |
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