Genetic risk factors for restenosis after percutaneous coronary intervention in Kazakh population

Autor: Elena Zholdybayeva, Olga Visternichan, Pavel Tarlykov, Yerlan M. Ramanculov, Akbota Aitkulova, Gulmira N. Kulmambetova, Yerkebulan A. Talzhanov, Dana Taizhanova, Aisha N. Iskakova, Aliya U. Dzholdasbekova
Jazyk: angličtina
Předmět:
Male
0301 basic medicine
Genotyping
medicine.medical_specialty
Haploview
medicine.medical_treatment
Population
SNP
Single-nucleotide polymorphism
Kazakh
030204 cardiovascular system & hematology
Logistic regression
Polymorphism
Single Nucleotide
Receptor
Angiotensin
Type 1
Coronary Restenosis
03 medical and health sciences
Percutaneous Coronary Intervention
0302 clinical medicine
Restenosis
Risk Factors
Internal medicine
Drug Discovery
Genetics
medicine
Humans
Genetic Predisposition to Disease
education
Molecular Biology
Genetic Association Studies
Aged
education.field_of_study
business.industry
Haplotype
Percutaneous coronary intervention
Middle Aged
medicine.disease
Kazakhstan
language.human_language
Interleukin-10
Coronary heart disease
030104 developmental biology
Haplotypes
Case-Control Studies
language
Molecular Medicine
Female
Primary Research
business
Zdroj: Human Genomics
ISSN: 1479-7364
DOI: 10.1186/s40246-016-0077-z
Popis: Background After coronary stenting, the risk of developing restenosis is from 20 to 35 %. The aim of the present study is to investigate the association of genetic variation in candidate genes in patients diagnosed with restenosis in the Kazakh population. Methods Four hundred fifty-nine patients were recruited to the study; 91 patients were also diagnosed with diabetes and were excluded from the sampling. DNA was extracted with the salting-out method. The patients were genotyped for 53 single-nucleotide polymorphisms. Genotyping was performed on the QuantStudio 12K Flex (Life Technologies). Differences in distribution of BMI score among different genotype groups were compared by analysis of variance (ANOVA). Also, statistical analysis was performed using R and PLINK v.1.07. Haplotype frequencies and LD measures were estimated by using the software Haploview 4.2. Results A logistic regression analysis found a significant difference in restenosis rates for different genotypes. FGB (rs1800790) is significantly associated with restenosis after stenting (OR = 2.924, P = 2.3E−06, additive model) in the Kazakh population. CD14 (rs2569190) showed a significant association in the additive (OR = 0.08033, P = 2.11E−09) and dominant models (OR = 0.05359, P = 4.15E−11). NOS3 (rs1799983) was also highly associated with development of restenosis after stenting in additive (OR = 20.05, P = 2.74 E−12) and recessive models (OR = 22.24, P = 6.811E−10). Conclusions Our results indicate that FGB (rs1800790), CD14 (rs2569190), and NOS3 (rs1799983) SNPs could be genetic markers for development of restenosis in Kazakh population. Adjustment for potential confounder factor BMI gave almost the same results.
Databáze: OpenAIRE
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