Synthesis of optically-active hexadecyl thiophosphoryl-1-d-myo-inositol: A thiophosphate analog of phosphatidylinositol
| Autor: | Anatoliy S. Bushnev, Vitally I. Shvets, H.Stewart Hendrickson, Elizabeth K. Hendrickson |
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| Rok vydání: | 1994 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Clinical Biochemistry Bacillus cereus Pharmaceutical Science In Vitro Techniques Phosphatidylinositols Biochemistry Substrate Specificity Thiophosphate chemistry.chemical_compound Phosphoinositide Phospholipase C Drug Discovery Inositol Phosphatidylinositol Molecular Biology Molecular Structure Phospholipase C biology Phosphoric Diester Hydrolases Chemistry Phosphatidylinositol Diacylglycerol-Lyase Organic Chemistry Substrate (chemistry) Stereoisomerism Optically active biology.organism_classification Kinetics Molecular Medicine Dimethyl phosphite |
| Zdroj: | Bioorganic & Medicinal Chemistry. 2:147-151 |
| ISSN: | 0968-0896 |
| DOI: | 10.1016/s0968-0896(00)82010-6 |
| Popis: | The synthesis of optically-active hexadecyl thiophosphoryl-1- d -myo-inositol 11 was accomplished from 2,3-O-( d -1′,7′,7′-trimethyl[2.2.1]bicyclohept-2′-ylidene)-4,5,6-O-tris(methoxymethyl)- d -myo-inositol 6 or 2,3,4,5,6-O-pentakis(methoxymethyl)- d -myo-inositol 14, using the Arbusov reaction of their dimethyl phosphite derivatives 7 and 15 with N-hexadecyl thiophthalimide 8. This product was a substrate for phosphatidylinositol-specific phospholipase C from Bacillus cereus. |
| Databáze: | OpenAIRE |
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