The impact of performance status on tuberculosis-related death among elderly patients with lung tuberculosis: A competing risk regression analysis
| Autor: | Akihiko Goto, Kosaku Komiya, Takamasa Kan, Jun-ichi Kadota, Osamu Takahashi, Shuichi Takikawa, Zoie Shui-Yee Wong, Tetsuyuki Yoshimatsu, Kokoro Honjo, Sonoe Uchida |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty Tuberculosis 030106 microbiology Competing risks Risk Assessment Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Elderly people Pharmacology (medical) In patient Poor performance status 030212 general & internal medicine Tuberculosis Pulmonary Serum Albumin Aged Retrospective Studies Aged 80 and over Performance status business.industry Lung tuberculosis Regression analysis Prognosis medicine.disease Infectious Diseases Regression Analysis Female business |
| Zdroj: | Journal of Infection and Chemotherapy. 26:69-75 |
| ISSN: | 1341-321X |
| Popis: | While advanced age is a main prognostic factor in patients with tuberculosis, the factors that specifically affect tuberculosis-related death are unclear because elderly people are at a risk for other age-related lethal diseases. We aimed to assess the impact of performance status on tuberculosis-related death among elderly patients with lung tuberculosis. Elderly patients (≥65 years of age) admitted to our hospital for bacteriologically-diagnosed lung tuberculosis were included, and analyzed the influence of performance status on tuberculosis-related in-hospital death, with non-tuberculosis-related death as a competing risk. Forty and 19 of the 275 patients died from tuberculosis-related causes and non-tuberculosis-related causes, respectively. The tuberculosis-related death group had a greater number of patients with a poor performance status (defined as category 3 and 4 [HR 21.022; 95%CI 2.881-153.414; p = 0.003]), a lower serum albumin level (HR 0.179; 95%CI 0.090-0.359; p 0.001) and a higher C-reactive protein level (HR1.076; 95%CI 1.026-1.127; p = 0.002). A multivariate competing risk regression analysis showed that a poor performance status (HR 7.311; 95%CI 1.005-53.181; p = 0.049) and low albumin level (HR 0.228; 95%CI 0.099-0.524); p = 0.001) significantly predicted tuberculosis-related death. Performance status can be a useful scale for predicting tuberculosis-related death among elderly patients with pulmonary tuberculosis. |
| Databáze: | OpenAIRE |
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