Circadian pattern of large neutral amino acids, glucose, insulin, and food intake in anorexia nervosa and bulimia nervosa
| Autor: | Reinhard J. Tuschl, Reinhold G. Laessle, Ulrich Schweiger, Manfred M. Fichter, Detlev Werner, Karl-Martin Pirke, Jürgen-Christian Krieg, Gerhard Brunner, Wolfgang Schreiber |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Anorexia Nervosa Endocrinology Diabetes and Metabolism medicine.medical_treatment Eating Endocrinology Internal medicine medicine Humans Insulin Circadian rhythm Amino Acids Bulimia Pancreatic hormone Triiodothyronine business.industry Bulimia nervosa Metabolism medicine.disease Circadian Rhythm Glucose Anorexia nervosa (differential diagnoses) Anorectic Female business |
| Zdroj: | Metabolism. 40:503-507 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(91)90231-k |
| Popis: | Insulin, glucose, and large neutral amino acids (LNAA) were studied in 10 patients with anorexia nervosa, 13 patients with bulimia nervosa, and 15 healthy controls. Blood samples were collected at hourly intervals during the day and at two-hour intervals during the night over a 24-hour period. Ad libitum caloric and relative carbohydrate intake was significantly reduced in the anorectic and bulimic patients. Elevated concentrations of β-hydroxybutyric acid (BHBA) were seen in the bulimic group, and low triiodothyronine (T 3 ) concentrations in the anorectic group. Mean plasma glucose and insulin concentrations were significantly lowered in both groups. The tryptophan (Trp) to LNAA ratio was reduced in anorectic, but not in bulimic patients. These findings suggest that Trp influx into the brain is reduced in anorectic patients, possibly impairing central serotonergic function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|