Late-onset myasthenia gravis is predisposed to become generalized in the elderly
| Autor: | Mitsuyo Ishida, Yuishin Izumi, Ryuji Kaji, Kenta Sato, Kazuya Kondo, Nobuaki Yamamoto, Takahiro Furukawa, Waka Sakai, Yoshimichi Miyazaki, Takao Mitsui, Ryosuke Miyamoto, Yoshihiko Nishida, Naoko Matsui, Wataru Sako, Koji Fujita |
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| Rok vydání: | 2016 |
| Předmět: |
Pediatrics
medicine.medical_specialty medicine.medical_treatment Late-onset myasthenia gravis Late onset EOMG early-onset myasthenia gravis AChR acetylcholine receptor PIS MGFA post-intervention status lcsh:RC346-429 Crisis 03 medical and health sciences LOMG late-onset myasthenia gravis Elderly 0302 clinical medicine DM diabetes mellitus PSL prednisolone Diabetes mellitus IVIg intravenous immunoglobulin medicine 030212 general & internal medicine Steroid lcsh:Neurology. Diseases of the nervous system MGFA Myasthenia Gravis Foundation of America Hyperplasia business.industry Antibody titer Clinical course Thymectomy medicine.disease humanities Myasthenia gravis MG-ADL myasthenia gravis activities of daily living score ChE-I cholinesterase inhibitor PE plasmapheresis Neurology Immunology Prednisolone Original Article Plasmapheresis business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | eNeurologicalSci, Vol 2, Iss C, Pp 17-20 (2016) eNeurologicalSci |
| ISSN: | 2405-6502 |
| DOI: | 10.1016/j.ensci.2016.02.004 |
| Popis: | Objective The continuous increase in the number of patients presenting with late-onset myasthenia gravis (LOMG) underscores the need for a better understanding of the clinical course and the establishment of an optimal therapeutic strategy. We aimed to clarify factors associated with clinical outcomes in LOMG. Methods We retrospectively reviewed the clinical profiles of 40 patients with early-onset MG (EOMG) (onset age: 49 years or younger), 30 patients with non-elderly LOMG (onset age: 50–64 years), and 28 patients with elderly LOMG (onset age: 65 years or older) and compared the subgroups according to onset age and thymus status. The evaluated parameters were MGFA classification before treatment, MG-ADL score, complicating diseases, antibody titer, treatment, and MGFA post-intervention status. Results Elderly LOMG patients showed transition to generalized symptoms at a higher frequency and underwent thymectomy less frequently than EOMG and non-elderly LOMG patients (p Highlights • Elderly LOMG patients showed transition to generalized symptoms at a higher frequency. • Thymectomized LOMG patients without thymoma showed crisis less frequently. • Our study showed that elderly LOMG patients are more prone to severity. |
| Databáze: | OpenAIRE |
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