Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: A prospective study
| Autor: | Lucía Lourido, Cristina Regueiro, Naomi Diz-Rosales, Cristina Ruiz-Romero, José Antonio Pinto Tasende, Antonio Mera-Varela, K. Hambardzumyan, Sergio Vilaboa-Galán, Eva Perez-Pampin, Saedis Saevarsdottir, Flor Picchi, Antonio Gonzalez, Francisco J. Blanco, Peter Nilsson, Carlos Fernández-López |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Chromosomal Proteins Non-Histone Antigen arrays Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology Antigen Internal medicine medicine Humans Clinical significance Prospective Studies 030212 general & internal medicine Rheumatoid arthritis Prospective cohort study 030203 arthritis & rheumatology biology Tumor Necrosis Factor-alpha business.industry Microfilament Proteins Adalimumab Autoantibody CENPF Response medicine.disease Infliximab 3. Good health Anesthesiology and Pain Medicine Antirheumatic Agents biology.protein Antibody Autoimmunity profiling business medicine.drug |
| Zdroj: | RUC: Repositorio da Universidade da Coruña Universidade da Coruña (UDC) RUC. Repositorio da Universidade da Coruña instname |
| ISSN: | 0049-0172 |
| Popis: | [Abstract] Background: One-third of rheumatoid arthritis (RA) patients demonstrate no clinical improvement after receiving tumor necrosis factor inhibitors (TNFi). The presence of serum autoantibodies is a hallmark in RA and may provide information on future response to treatment. The aim of this prospective study was to search for novel serum autoantibodies useful to predict clinical response to TNFi. Methods: The autoantibody repertoire was profiled on RA patients treated with TNFi as a first line of biologic therapy (N = 185), who were recruited in three independent cohorts. The presence and levels of autoantibodies in serum at baseline were analysed in association with the clinical response after 24 weeks follow-up. A multiplex bead array built using antigens selected from an initial untargeted screening was employed to identify the autoantibodies on a discovery cohort (N = 50) and to verify and validate the results on verification (N = 61) and validation (N = 74) cohorts. Non-parametric tests, meta-analysis and Receiver Operating Curves (ROC) were performed in order to assess the clinical relevance of the observed findings. Results: Novel autoantibodies were associated with the clinical response to TNFi, showing different reactivity profiles among the different TNFi. The baseline levels of IgG antibodies against Centromere protein F (CENPF), a protein related to cell proliferation, were significantly (p |
| Databáze: | OpenAIRE |
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