Ticlopidine Improves Dialysis Clearance of Solutes in Uremic Patients by Reducing Blood Clotting in Dialyser Fibers
| Autor: | Milutinović S, Gasparović, Milutinović E, Buturović-Ponikvar J |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Ticlopidine Adolescent 030232 urology & nephrology Biomedical Engineering Urology Medicine (miscellaneous) Bioengineering 030204 cardiovascular system & hematology Placebo Phosphates Biomaterials 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Renal Dialysis Humans Urea Medicine Platelet Adverse effect Blood Coagulation Aged Uremia Creatinine Blood clotting business.industry General Medicine Middle Aged Blood Cell Count chemistry Platelet aggregation inhibitor Female business medicine.drug |
| Zdroj: | The International Journal of Artificial Organs. 16:249-252 |
| ISSN: | 1724-6040 0391-3988 |
| Popis: | Ticlopidine, a platelet aggregation inhibitor was tested, in a double blind comparative cross-over study versus placebo, in 51 dialysed uremic patients who had increased dialyser blood clotting (> 25 fibers clotted / dialyser). At the end of a 7-day treatment period with 250 mg daily, the clearance of urea, creatinine and phosphate was determined at 30 and 210 minutes of dialysis, as well as the number of fibers clotted at the end of dialysis. Ticlopidine improved dialyser clearances for urea, creatinine and phosphate from 165 ± 41 to 182 ± 35 (p < 0.01), 135 ± 37 to 143 ± 35 (p < 0.05), and 120 ± 36 to 130 ± 35 (p < 0.05) ml/min, respectively, at 30 min of HD and a similar effect was seen after 210 min of dialysis. The number of dialyser fibers clotted after dialysis was reduced by ticlopidine therapy from 110 ± 48 to 15 ± 8 (p < 0.01). Ticlopidine reduced the initial dialysis-induced drop in leucocyte count by 20% (p < 0.05); no change in platelet or erythrocyte count was observed. Two out of 51 patients experienced an adverse reaction from ticlopidine (cutaneous haematoma and minor gingival bleeding). We conclude that ticlopidine is an efficient and safe drug for dialysed uremic patients since it can reduce blood clotting and thereby increase dialysis efficiency. |
| Databáze: | OpenAIRE |
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