Stereospecific inhibition of non-opioid defeat analgesia in male mice by MDL 72832, a selective 5-HT1A receptor agonist
| Autor: | R. John Rodgers, Jon K. Shepherd |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Pharmacology Agonist Chemistry medicine.drug_class Stereoisomerism Ligand (biochemistry) Mice Basal (phylogenetics) Nociception Opioid Mice Inbred DBA Receptors Serotonin Reaction Time medicine Animals 5-HT1A receptor Spiro Compounds Analgesia Social Behavior 5-HT receptor medicine.drug Serotonin Agonist |
| Zdroj: | European Journal of Pharmacology. 182:581-585 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(90)90060-j |
| Popis: | The effects of MDL 72832, a potent and stereoselective ligand for 5-HT1A sites, on basal nociception and non-opioid defeat analgesia in male mice were examined. Neither (+)- nor (−)-MDL 72832 significantly altered basal tail-flick latencies. In contrast, (−)-MDL 72832 potently inhibited defeat analgesia (0.1–0.5 mg/kg i.p.), with similar effects produced by (+)-MDL 72832 only at substantially higher doses (3.0–5.0 mg/kg i.p.). These data clearly demonstrate a stereoselective action of this 5-HT1A ligand on non-opioid defeat analgesia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|