Effects of levocetirizine and diphenhydramine on regional glucose metabolic changes and hemodynamic responses in the human prefrontal cortex during cognitive tasks

Autor: Daigo Koike, Shoichi Watanuki, Kotaro Hiraoka, Hiroshi Watabe, Masayasu Miyake, Takayasu Ito, Attayeb Mohsen, Marcus Maurer, Manabu Tashiro, Rin Matsuda, Kazuko Takeda, Akie Inami, Asuka Kikuchi, Fairuz Binti Mohammadi Nasir, Junpei Sasakawa, Kazuhiko Yanai
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Time Factors
medicine.medical_treatment
Neuropsychological Tests
Levocetirizine
Cognition
0302 clinical medicine
Image Processing
Computer-Assisted
Pharmacology (medical)
Prefrontal cortex
Research Articles
Brain Mapping
Cross-Over Studies
Spectroscopy
Near-Infrared
Diphenhydramine
levocetirizine
Human brain
Healthy Volunteers
Psychiatry and Mental health
medicine.anatomical_structure
NIRS
sedation
Neurology
Anesthesia
Histamine H1 Antagonists
Female
Antihistamine
Research Article
medicine.drug
antihistamines
FDG‐PET
medicine.drug_class
diphenhydramine
Prefrontal Cortex
03 medical and health sciences
Double-Blind Method
Fluorodeoxyglucose F18
medicine
Humans
business.industry
Hemodynamics
Crossover study
Cetirizine
Glucose
030104 developmental biology
Positron-Emission Tomography
Sedative
Neurology (clinical)
business
030217 neurology & neurosurgery
Stroop effect
Zdroj: Human Psychopharmacology
ISSN: 0885-6222
DOI: 10.1002/hup.2655
Popis: Objective Antihistamines often have sedative side effects. This was the first study to measure regional cerebral glucose (energy) consumption and hemodynamic responses in young adults during cognitive tests after antihistamine administration. Methods In this double‐blind, placebo‐controlled, three‐way crossover study, 18 healthy young Japanese men received single doses of levocetirizine 5 mg and diphenhydramine 50 mg at intervals of at least six days. Subjective feeling, task performances, and brain activity were evaluated during three cognitive tests (word fluency, two‐back, and Stroop). Regional cerebral glucose consumption changes were measured using positron emission tomography with [18F]fluorodeoxyglucose. Regional hemodynamic responses were measured using near‐infrared spectroscopy. Results Energy consumption in prefrontal regions was significantly increased after antihistamine administration, especially diphenhydramine, whereas prefrontal hemodynamic responses, evaluated with oxygenated hemoglobin levels, were significantly lower with diphenhydramine treatment. Stroop test accuracy was significantly impaired by diphenhydramine, but not by levocetirizine. There was no significant difference in subjective sleepiness. Conclusions Physiological “coupling” between metabolism and perfusion in the healthy human brain may not be maintained under pharmacological influence due to antihistamines. This uncoupling may be caused by a combination of increased energy demands in the prefrontal regions and suppression of vascular permeability in brain capillaries after antihistamine treatment. Further research is needed to validate this hypothesis.
Databáze: OpenAIRE
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