Advances in Degradable Embolic Microspheres: A State of the Art Review
Autor: | Kathleen O'Connell, Lauren Kiri, Jensen Doucet, Robert J. Abraham, David M. Liu, Robert J. Lewandowski, Daniel Boyd, S. Kehoe |
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Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
Materials science Emerging technologies lcsh:Biotechnology Biomedical Engineering Review embolization 02 engineering and technology degradable bioresorbable 030218 nuclear medicine & medical imaging Microsphere Biomaterials Food and drug administration 03 medical and health sciences 0302 clinical medicine lcsh:TP248.13-248.65 Transarterial embolization medicine Medical physics Vascular embolization lcsh:R5-920 medicine.diagnostic_test resorbable Interventional radiology State of the art review 021001 nanoscience & nanotechnology microsphere Bland Embolization lcsh:Medicine (General) 0210 nano-technology |
Zdroj: | Journal of Functional Biomaterials, Vol 9, Iss 1, p 14 (2018) Journal of Functional Biomaterials |
ISSN: | 2079-4983 |
DOI: | 10.3390/jfb9010014 |
Popis: | Considerable efforts have been placed on the development of degradable microspheres for use in transarterial embolization indications. Using the guidance of the U.S. Food and Drug Administration (FDA) special controls document for the preclinical evaluation of vascular embolization devices, this review consolidates all relevant data pertaining to novel degradable microsphere technologies for bland embolization into a single reference. This review emphasizes intended use, chemical composition, degradative mechanisms, and pre-clinical safety, efficacy, and performance, while summarizing the key advantages and disadvantages for each degradable technology that is currently under development for transarterial embolization. This review is intended to provide an inclusive reference for clinicians that may facilitate an understanding of clinical and technical concepts related to this field of interventional radiology. For materials scientists, this review highlights innovative devices and current evaluation methodologies (i.e., preclinical models), and is designed to be instructive in the development of innovative/new technologies and evaluation methodologies. |
Databáze: | OpenAIRE |
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