Amine oxidases, programmed cell death, and tissue renewal
| Autor: | Robert A. Gramzinski, Ralph E. Parchment, G B Pierce |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Programmed cell death
Oxidoreductases Acting on CH-NH Group Donors Cell Survival Embryogenesis Melanoma Experimental Teratoma Embryo Cell Differentiation Extremities Embryoid body Biology Blastula Embryonic stem cell Cell biology Mice medicine.anatomical_structure Blastocyst embryonic structures Immunology medicine Inner cell mass Animals Homeostasis reproductive and urinary physiology |
| Zdroj: | Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 327(1239) |
| ISSN: | 0962-8436 |
| Popis: | Embryonal carcinoma cells, with embryonic (ECaE) or trophectodermal (ECaT) potential, have been used in a colony assay to determine regulatory mechanisms in the blastocyst. The mechnism that regulates ECaE and results in chimera formation is dependent upon a soluble factor in blastocoele fluid and contact with trophectoderm. Two mechanisms contribute to the regulation of ECaT: one involves a factor in blastocoele fluid and the other contact with either trophectoderm or inner cell mass which results in differentiation of the cells into trophectoderm, and the other involves the killing of at least 40% of the cells by blastocoele fluid alone. This cytotoxic activity probably causes the programmed cell death that occurs in the inner cell mass during blastulation as it loses the potential to differentiate into trophectoderm. A toxic activity similar to that of normal blastocysts has been obtained from embryoid bodies. This activity is caused by amine oxidase-dependent catabolism of polyamines, and it is postulated that programmed cell death in the embryo and chalone activity in the adult may have similar mechanisms. |
| Databáze: | OpenAIRE |
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