Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats
| Autor: | Guozhi Shen, Changbiao Wu, Qianying Wu, Xiaqing Li, Xinqi Zeng, Zhenglu Xie, Binbin Wu |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
type 1 diabetes QH301-705.5 Pharmacology Biology liver medicine.disease_cause General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound Plant science Polyol pathway medicine oxidative stress polyol pathway curcumin Biology (General) Protein kinase C protein kinase c Type 1 diabetes 030102 biochemistry & molecular biology General Immunology and Microbiology General Neuroscience medicine.disease 030104 developmental biology chemistry Curcumin General Agricultural and Biological Sciences Oxidative stress |
| Zdroj: | Open Life Sciences, Vol 12, Iss 1, Pp 452-459 (2017) |
| ISSN: | 2391-5412 |
| DOI: | 10.1515/biol-2017-0053 |
| Popis: | We investigated the effect of curcumin on liver anti-oxidative stress in the type 1 diabetic rat model induced by streptozotocin (STZ). Experimental diabetic rats were induced by STZ intraperitoneally. All rats were fed for 21 days including three groups of control (NC), diabetic model (DC) and curcumin-treated (Cur, 1.5 g/kg by gavage). The results showed that curcumin-treatment significantly decreased the blood glucose and plasma malondialdehyde levels, but significantly increased the plasma superoxide dismutase, glutathione peroxidase and reduced glutathione levels. Curcumin treatment decreased the activity of aldose reductase, but increased the plasma glucose-6-phosphate dehydrogenase, glucose synthetase and glucose-polymerizing activities. Curcumin treatment significantly decreased the protein of protein kinase C (PKC) and poly ADP ribose polymerase (PARP) expression in the Cur group compared with the DC group. Moreover, the sorbitol dehydrogenase activity was significantly decreased and deterred glucose enters into the polyol pathway leading to an increased NADPH content in the Cur group compared with the DC group. Our data provides evidence that oxidative stress in diabetic rats may be attenuated by curcumin by inhibiting polyol pathway associated with down-regulated expression of PKC and PARP, as evidenced by both an increase the antioxidant enzymes levels and glycogen biosynthesis enzymes activities. |
| Databáze: | OpenAIRE |
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