Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults
| Autor: | Atsuro Uchida, Kanako Izumi-Nagai, Yohei Tomita, Kazuo Tsubota, Misa Suzuki, Mariko Sasaki, Seiji Miyake, Hiroshi Mochimaru, Hajime Shinoda, Takashi Koto, Norihiro Nagai, Saori Kobayashi, Yoko Ozawa |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Lutein genetic structures Enzyme-Linked Immunosorbent Assay Photometry chemistry.chemical_compound Young Adult Blood serum Zeaxanthins Ophthalmology Surveys and Questionnaires Macular Pigment medicine Humans Macula Lutea Carotenoid Chromatography High Pressure Liquid chemistry.chemical_classification Cholesterol business.industry food and beverages General Medicine Middle Aged eye diseases Healthy Volunteers Zeaxanthin Lipoproteins LDL chemistry Low-density lipoprotein Xanthophyll Female sense organs business Densitometry |
| Zdroj: | Retina (Philadelphia, Pa.). 35(4) |
| ISSN: | 1539-2864 |
| Popis: | To analyze the association between macular pigment optical density (MPOD), which reflects lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) in the macula, and background characteristics.Fifty-five healthy adult volunteers were analyzed. Macular pigment optical density was measured using a heterochromatic flicker photometry technique, and serum concentrations of carotenoids and lipoproteins were by high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. Dietary intake of nutrient was determined by a validated self-administered questionnaire on ingestion frequency.Macular pigment optical density was positively correlated with serum concentrations of L and Z and dietary L intake and inversely correlated with serum oxidized low-density lipoprotein (LDL). Although MPOD decreased with age (95% confidence interval, -0.011 to -0.002; correlation coefficient, -0.269; P = 0.007), serum L/Z and dietary L intake did not. In contrast, serum oxidized LDL was positively correlated with age (95% confidence interval, 0.69-2.34; correlation coefficient, 0.333; P = 0.0004). After adjusting for age, sex, and oxidized LDL, serum L was positively correlated with MPOD (95% confidence interval, 0.88-1.69; P = 0.000001). After adjusting for age, sex, and serum L, serum oxidized LDL was inversely correlated with MPOD (95% confidence interval, -0.002 to -0.0004; P = 0.006).Macular pigment optical density was inversely correlated with serum oxidized LDL. Further study to know the impact of oxidized LDL on MPOD may be warranted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|