Noninvasive Detection of Subclinical Coronary Atherosclerosis Coupled With Assessment of Changes in Plaque Characteristics Using Novel Invasive Imaging Modalities
Autor: | Johannes A. Schaar, Patrick W. Serruys, Frits Mastik, Andrew Zalewski, Nico R. Mollet, Marco Valgimigli, Filippo Cademartiri, Georgios Sianos, Eugene P. McFadden, Marie-Angèle Morel, Bianca Backx, Gerrit-Anne van Es, Pim J. de Feyter, Carlos Van Mieghem, Sebastiaan de Winter, Nico Bruining, Dick Goedhart, Gaston A. Rodriguez Granillo, Anton F. W. van der Steen, Willem J. van der Giessen |
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Přispěvatelé: | Cardiology, Radiology & Nuclear Medicine |
Rok vydání: | 2006 |
Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Vascular disease Echogenicity medicine.disease Coronary arteries medicine.anatomical_structure Intravascular ultrasound Conventional PCI medicine Biomarker (medicine) Radiology business Cardiology and Cardiovascular Medicine Coronary atherosclerosis Subclinical infection |
Zdroj: | Journal of the American College of Cardiology, 47(6), 1134-1142. Elsevier Inc. |
ISSN: | 0735-1097 |
DOI: | 10.1016/j.jacc.2005.09.075 |
Popis: | Objectives Our purpose was to assess noninvasive imaging in detection of subclinical atherosclerosis and to examine novel invasive modalities to describe prevalence and temporal changes in putative characteristics of “high-risk” plaques. Background Conventional coronary imaging cannot identify “high-risk” lesions. Methods Conventional (quantitative angiography and intravascular ultrasound [IVUS]) and novel imaging (IVUS-based palpography and gray scale echogenicity) were performed at baseline and 6 months later in 67 patients with diverse clinical presentations. Different imaging techniques were compared within a common segment defined by multislice computed tomography (MSCT). Results Compared with IVUS, the sensitivity, specificity, and positive and negative predictive value of MSCT for detecting significant plaque was 86%, 69%, 90%, and 61%, respectively. In coronary arteries with Conclusions Mild angiographic disease is associated with large atherosclerotic plaques on MSCT. Conventional invasive coronary imaging reveals static luminal and plaque dimensions on standard medical therapy with plaque hypoechogenicity remaining unchanged over the 6-month period. By contrast, palpography measurements of strain correlate with clinical presentation and significantly decrease on standard medical therapy. Novel imaging modalities, such as palpography, might provide insights into plaque biology and might eventually serve as intermediate end points in interventional trials. |
Databáze: | OpenAIRE |
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