Insulator Protein Su(Hw) Is Indispensable for Amplification of Part of Drosophila Amplicons in Follicular Cells (DAFCs) during Early Oogenesis
| Autor: | M. Yu. Mazina, N. E. Vorobyova, A. N. Krasnov |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Regulation of gene expression Transcription Genetic Biophysics General Chemistry General Medicine Insulator (genetics) Amplicon Biology Biochemistry Oogenesis Cell biology Repressor Proteins 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Drosophila melanogaster Gene Expression Regulation Transcription (biology) 030220 oncology & carcinogenesis Animals Drosophila Proteins Transcription Repressor |
| Zdroj: | Doklady. Biochemistry and biophysics. 479(1) |
| ISSN: | 1608-3091 |
| Popis: | We found that the Su(Hw) insulator protein binds to all known Drosophila amplicons in follicular cells (DAFCs). Su(Hw) binding is required for ORC replication complex positioning on part of DAFCs during early oogenesis. Our data allow us to expand the current view on the role of the Su(Hw) protein in Drosophila oogenesis as a transcription repressor. We assume that Su(Hw) is involved in the coordination of transcription and replication processes during oogenesis in Drosophila. |
| Databáze: | OpenAIRE |
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