Cancer cells, adipocytes and matrix metalloproteinase 11: a vicious tumor progression cycle
| Autor: | Marie-Christine Rio, Elena Roza Motrescu |
|---|---|
| Přispěvatelé: | Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I, Peney, Maité, Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2008 |
| Předmět: |
Cell signaling
Clinical Biochemistry Adipose tissue Cell Communication Biology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Matrix Metalloproteinase 11 MESH: Matrix Metalloproteinase 11 Neoplasms Adipocyte MESH: Cell Communication Adipocytes medicine Animals Humans MESH: Animals MESH: Neoplasms Molecular Biology MESH: Adipocytes Neoplasm Staging 030304 developmental biology 0303 health sciences [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] MESH: Humans Cancer MESH: Neoplasm Staging medicine.disease [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] Desmoplasia chemistry Adipogenesis Tumor progression 030220 oncology & carcinogenesis Cancer cell Disease Progression Cancer research MESH: Disease Progression medicine.symptom |
| Zdroj: | Biological Chemistry Biological Chemistry, De Gruyter, 2008, 389 (8), pp.1037-41 Biological Chemistry, 2008, 389 (8), pp.1037-41 |
| ISSN: | 1437-4315 1431-6730 |
| Popis: | This brief review focuses on the emerging role of matrix metalloproteinase 11 (MMP-11) in cancer progression. It has recently been shown that MMP-11 is induced in adipose tissue by cancer cells as they invade their surrounding environment. MMP-11 negatively regulates adipogenesis by reducing pre-adipocyte differentiation and reversing mature adipocyte differentiation. Adipocyte dedifferentiation in turn leads to the accumulation of non-malignant peritumoral fibroblast-like cells, which favor cancer cell survival and tumor progression. This MMP-11-mediated bi-directional cross-talk between invading cancer cells and adjacent adipocytes/pre-adipocytes highlights the central role that MMP-11 plays during tumor desmoplasia and represents a molecular link between obesity and cancer. |
| Databáze: | OpenAIRE |
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