Pro-inflammatory cytokine alterations in unaffected first-degree relatives of schizophrenia patients
| Autor: | A. Kurtulmus |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Kurtulmus A.
-Pro-inflammatory cytokine alterations in unaffected first-degree relatives of schizophrenia patients- EUROPEAN PSYCHIATRY cilt.64 2021 Psychiatry and Mental health Cytokine business.industry Schizophrenia medicine.medical_treatment Immunology medicine First-degree relatives business medicine.disease |
| ISSN: | 0924-9338 |
| Popis: | IntroductionA growing body of evidence in both chronic and first-episode schizophrenia report increased expression of pro-inflammatory substances in the blood and cerebrospinal fluid of patients. However, there is not much data in the literature on immune alterations in unaffected first-degree relatives (FDRs) of the patients.ObjectivesWe aimed to evaluate inflammatory aberrancies in patients with schizophrenia, their unaffected first-degree relatives (FDRs) and healthy controls.Methods50 chronic, stable schizophrenia patients, 42 FDRs and 40 healthy subjects with no family history (HCSs) were recruited to the study. IL-1β, IL-6, TNF-a and CRP levels were measured. Complete blood counts, fasting glucose and lipid levels were analyzed and neutrofil-lymohocyte ratio (NLR) were calculated.ResultsThere was a significant group difference in all cytokine levels after controlling for age, gender, smoking status, comorbid medical diseases, BMI and blood glucose and tyrigliseride levels (pConclusionsOur results support the role of inflammatory aberrancies in the pathophysiology of schizophrenia. The finding of abnormal cytokine levels both in schizophrenic patients and FDRs indicates that such immunological alterations are not exclusive to the patients and can be possible endophenotypes for the disorder.DisclosureNo significant relationships. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|