Circulating miRNAs as biomarkers in diffuse large B-cell lymphoma: a systematic review
| Autor: | Javier Arzuaga-Mendez, Elixabet Lopez-Lopez, Maria Lopez-Santillan, Africa Garcia-Orad, Ane Larrabeiti-Etxebarria |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty diagnosis Population lymphoma Review 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine microRNA medicine education education.field_of_study business.industry Cancer Extracellular vesicle medicine.disease Lymphoma Circulating MicroRNA 030104 developmental biology classification 030220 oncology & carcinogenesis Biomarker (medicine) prognosis circulating microRNA business Diffuse large B-cell lymphoma |
| Zdroj: | Addi. Archivo Digital para la Docencia y la Investigación instname Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.25230 |
| Popis: | Diffuse large B-cell lymphoma (DLBCL) is an aggressive and heterogeneous malignancy, with highly variable outcomes among patients. Although classification and prognostic tools have been developed, standard therapy still fails in 30-40% of patients. Hence, identification of novel biomarkers is needed. Recently, circulating microRNAs (miRNAs) have been suggested as non-invasive biomarkers in cancer. Our aim was to review the potential role of circulating miRNAs as biomarkers for diagnosis, classification, prognosis, and treatment response in DLBCL. We performed a search in PubMed using the terms [(('Non-coding RNA') OR ('microRNA' OR 'miRNA' OR 'miR') OR ('exosome') OR ('extracellular vesicle') OR ('secretome')) AND ('Diffuse large B cell lymphoma' OR 'DLBCL')] to identify articles that evaluated the impact of circulating miRNAs as diagnosis, subtype, treatment response or prognosis biomarkers in DLBCL in human population. Among the twelve articles that met the inclusion criteria, eleven considered circulating miRNAs as biomarkers for diagnosis, two for classification, and five for prognosis or treatment response. The limited number of studies performed and lack of consistency in results make it difficult to draw conclusions about the role of circulating miRNAs as non-invasive biomarkers in DLBCL. Although the preliminary associations observed seem promising, the only consistent result is the upregulation of mir-21 in DLBCL patients, which could be a biomarker for diagnosis. Further studies are needed. |
| Databáze: | OpenAIRE |
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