Engineered Mesenchymal Stem Cell/Nanomedicine Spheroid as an Active Drug Delivery Platform for Combinational Glioblastoma Therapy
| Autor: | Ha Yeun Ji, Ki-Bum Lee, Smruthi Suryaprakash, Dantong Huang, Hyeon-Yeol Cho, Mingqiang Li, Rachel L. Mintz, Hanze Hu, Kam W. Leong, Dan Shao, C. H. Quek, Juli R. Bagó, Shawn Hingtgen, Yeh-Hsing Lao |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Cell Bioengineering 02 engineering and technology Targeted therapy Drug Delivery Systems In vivo Cell Movement Spheroids Cellular Medicine Humans General Materials Science Cell Engineering business.industry Mechanical Engineering Mesenchymal stem cell Spheroid Mesenchymal Stem Cells General Chemistry 021001 nanoscience & nanotechnology Condensed Matter Physics medicine.disease Combined Modality Therapy Viral Tropism medicine.anatomical_structure Nanomedicine Drug delivery Cancer research 0210 nano-technology business Glioblastoma |
| Zdroj: | Nano letters. 19(3) |
| ISSN: | 1530-6992 |
| Popis: | Mesenchymal stem cell (MSC) has been increasingly applied to cancer therapy because of its tumor-tropic capability. However, short retention at target tissue and limited payload option hinder the progress of MSC-based cancer therapy. Herein, we proposed a hybrid spheroid/nanomedicine system, comprising MSC spheroid entrapping drug-loaded nanocomposite, to address these limitations. Spheroid formulation enhanced MSC's tumor tropism and facilitated loading of different types of therapeutic payloads. This system acted as an active drug delivery platform seeking and specifically targeting glioblastoma cells. It enabled effective delivery of combinational protein and chemotherapeutic drugs by engineered MSC and nanocomposite, respectively. In an in vivo migration model, the hybrid spheroid showed higher nanocomposite retention in the tumor tissue compared with the single MSC approach, leading to enhanced tumor inhibition in a heterotopic glioblastoma murine model. Taken together, this system integrates the merits of cell- and nanoparticle- mediated drug delivery with the tumor-homing characteristics of MSC to advance targeted combinational cancer therapy. |
| Databáze: | OpenAIRE |
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