Reduction in peripheral blood K cells and activated T cells in primary biliary cirrhosis
| Autor: | K G Gray, G P Sandilands, G. Watkinson, Peter R. Mills, M A Thomas, R. N. M. Macsween, R J Holden, F M Reid |
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| Rok vydání: | 1977 |
| Předmět: |
Adult
medicine.medical_specialty T-Lymphocytes Gastroenterology Hepatitis Leukocyte Count Primary biliary cirrhosis Lymphocyte subpopulations Internal medicine medicine Humans Cytotoxicity Aged B-Lymphocytes Liver Cirrhosis Biliary business.industry Antibody-Dependent Cell Cytotoxicity Middle Aged medicine.disease digestive system diseases Peripheral blood Killer Cells Natural Chronic disease Antibody-dependent cell cytotoxicity Chronic Disease business Research Article |
| Zdroj: | Gut. 18:1017-1020 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.18.12.1017 |
| Popis: | Lymphocyte subpopulations were measured in the peripheral blood of 13 patients with primary biliary cirrhosis (PBC), 13 with chronic active hepatitis (CAH), and 16 age- and sex-matched normal subjects. A significant, relative and absolute, reduction in activated T cells and K cells, compared with that in normal subjects, was found in PBC but not in CAH. The reduction in K cells observed in PBC was found to be accompanied by a parallel decrease in lymphocyte-mediated antibody-dependent cytotoxicity. |
| Databáze: | OpenAIRE |
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