Cerebrospinal fluid procalcitonin as a biomarker of bacterial meningitis in neonates
| Autor: | Wasim A. Wani, Z Reshi, Muzaffar Ahmad Malik, Mudasir Nazir, J Iqbal, S Wajid |
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| Rok vydání: | 2017 |
| Předmět: |
Calcitonin
Male medicine.medical_specialty India Spinal Puncture Gastroenterology Procalcitonin Meningitis Bacterial Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid 030225 pediatrics Internal medicine medicine Humans Prospective Studies 030212 general & internal medicine Cerebrospinal Fluid medicine.diagnostic_test Obstetrics business.industry Lumbar puncture Infant Newborn Area under the curve Obstetrics and Gynecology medicine.disease ROC Curve Pediatrics Perinatology and Child Health Absolute neutrophil count Biomarker (medicine) Female business Procalcitonin Measurement Meningitis Biomarkers |
| Zdroj: | Journal of Perinatology. 37:927-931 |
| ISSN: | 1476-5543 0743-8346 |
| DOI: | 10.1038/jp.2017.73 |
| Popis: | The objective of the study was to study the performance of cerebrospinal fluid (CSF) procalcitonin as a marker for bacterial meningitis in neonates, and to determine its optimal ‘cutoff’ in CSF that can be called significant for the diagnosis. Neonates qualifying for lumbar puncture were prospectively studied. Procalcitonin and established CSF parameters were recorded. At a cut-off value of 0.33 ng ml−1, CSF procalcitonin had a sensitivity of 0.92, specificity of 0.87, with positive and negative likelihood ratios of 7.13 and 0.092, respectively. The area under the curve for different CSF parameters was: 0.926 (0.887 to 0.964) (P |
| Databáze: | OpenAIRE |
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