Evaluation of Nanotargeted 111In-Cyclic RGDfK-Liposome in a Human Melanoma Xenotransplantation Model
| Autor: | Si-Yen Liu, Wei-Chuan Hsu, Chih-Hsien Chang, Sheng-Nan Lo, Wan-Chi Lee, Te-Wei Lee |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Xenotransplantation medicine.medical_treatment Cell Peptide αVβ3 integrin Catalysis lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine 111In-cyclic RGDfK-liposome In vivo medicine Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy chemistry.chemical_classification Liposome Reactive oxygen species Nanotargeted liposome Organic Chemistry General Medicine In vitro Computer Science Applications 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) lcsh:QD1-999 chemistry 030220 oncology & carcinogenesis Biophysics Human melanoma |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 1099, p 1099 (2021) International Journal of Molecular Sciences Volume 22 Issue 3 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22031099 |
| Popis: | Nanotargeted liposomes may be modified with targeting peptide on the surface of a prepared liposome to endow specificity and elevate targeting efficiency. The aim of this study was to develop a radioactive targeted nanoparticle, the 111In-cyclic RGDfK-liposome, and its advantage of recognizing the &alpha V&beta 3 integrin was examined. The cyclic RGDfK modified liposomes were demonstrated the ability to bind the &alpha 3 integrin expressed on the surface of human melanoma cell in vitro and in vivo. The effects of the cyclic RGDfK-liposome on the functioning of phagocytes was also examined, showing no considerable negative effects on the engulfment of bacteria and the generation of reactive oxygen species. Based upon these findings, the cyclic RGDfK- liposome is said to be a promising agent for tumor imaging. |
| Databáze: | OpenAIRE |
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