Expression of inositol polyphosphate 4‐phosphatase type II and the prognosis of oral squamous cell carcinoma
| Autor: | Zhi-Jun Sun, Yao Xiao, Hao Li, Qi-Chao Yang, Shao-Chen Yang, Cong-Cong Wu |
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| Rok vydání: | 2020 |
| Předmět: |
0206 medical engineering
Phosphatase 02 engineering and technology Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Downregulation and upregulation Biomarkers Tumor Humans Medicine Inositol General Dentistry Pathological Tissue microarray business.industry 030206 dentistry Prognosis 020601 biomedical engineering Phosphoric Monoester Hydrolases stomatognathic diseases chemistry Carcinoma Squamous Cell Cancer research Mouth Neoplasms DNA microarray business Immunostaining |
| Zdroj: | European Journal of Oral Sciences. 128:37-45 |
| ISSN: | 1600-0722 0909-8836 |
| Popis: | Inositol polyphosphate 4-phosphatase type II (INPP4B) is a phosphoinositide phosphatase that plays complex roles in the pathogenesis of different tumors. We aimed to explore the expression, clinicopathological significance, and prognostic value of INPP4B in oral squamous cell carcinoma (OSCC). Tissue microarrays that included samples from 176 primary OSCCs, 42 normal mucosae, and 69 dysplastic tissues were used for immunostaining analyses of INPP4B protein. Aperio ScanScope CS scanner and aperio quantification software were used to scan the microarrays and score the staining, respectively. We also evaluated the correlation between INPP4B expression and clinical parameters, pathological grades, node-positive status, and immune-related markers. Expression of INPP4B was statistically significantly upregulated in human primary OSCC tissues compared with dysplastic and normal tissues. Additionally, we found that patients with strong expression of INPP4B had a statistically significantly poorer overall survival than patients with weak expression of INPP4B. Furthermore, our study indicated that expression of INPP4B in OSCC was positively associated with expression of p-S6Ser235/236 , p-CADSer1859 , and certain immune checkpoints (B7-H4, Galectin-9). Therefore, INPP4B may be an independent prognostic indicator for patients with OSCC, in which it might function as an oncoprotein. |
| Databáze: | OpenAIRE |
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