Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Autor:	Thanh Chung Pham, Yeonghwan Choi, Juyoung Yoon, Songyi Lee, Van-Nghia Nguyen
Rok vydání:	2021
Předmět:	Photosensitizing Agents Chemistry medicine.medical_treatment Photodynamic therapy Nanotechnology General Chemistry eye diseases Review article Cancer treatment Photochemotherapy Neoplasms medicine Humans Photosensitizer Reactive Oxygen Species
Zdroj:	Chemical Reviews. 121:13454-13619
ISSN:	1520-6890 0009-2665
Popis:	This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d853c189df6e42f81685224a3088f8 https://doi.org/10.1021/acs.chemrev.1c00381 Zobrazit plný text záznamu