Dissociation of maximum concentration of kanamycin in plasma and perilymph from ototoxic effect
| Autor: | Robert E. Brummett, Donna L. Himes, Rickie R. Davis, Thomas W. Bendrick |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Microbiology (medical)
Time Factors Guinea Pigs Cmax Perilymph Nephrotoxicity Ototoxicity Kanamycin medicine Tobramycin Animals Pharmacology (medical) Dosing Pharmacology business.industry Aminoglycoside Ear Labyrinthine Fluids medicine.disease Infectious Diseases Anesthesia Evoked Potentials Auditory Netilmicin business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 14:291-302 |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | Kanamycin was administered in total daily doses of 0 (vehicle), 100, 200 or 300 mg/kg to different groups of guinea pigs for two weeks. These total daily doses were administered according to three different dosing schedules, either as a single injection given once a day, divided into two equal doses and given twice a day, or divided into four equal doses and administered four times a day. It was found that the magnitude of the ototoxicity resulting from kanamycin administration was related to the total daily dose alone and not the dosing schedule. This lack of relationship between the dosing schedule and the magnitude of the ototoxicity due to kanamycin is the reverse of that reported for the nephrotoxicity resulting from gentamicin, tobramycin and netilmicin. |
| Databáze: | OpenAIRE |
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