Magnetic resonance spectroscopic findings in neuro-Behçet disease
| Autor: | Stephen M Yoest, Frederick C Stebner, Shawna E Scully |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Magnetic Resonance Spectroscopy Axonal loss Disease Creatine chemistry.chemical_compound Myelin medicine Choline Humans medicine.diagnostic_test business.industry Behcet Syndrome Magnetic resonance imaging General Medicine Spinal cord medicine.disease eye diseases stomatognathic diseases medicine.anatomical_structure chemistry Neurology (clinical) Nervous System Diseases business Vasculitis |
| Zdroj: | The neurologist. 10(6) |
| ISSN: | 1074-7931 |
| Popis: | Background Behcet disease is a heterogeneous, multisystem disorder with elements of both environmental and autoimmune pathologic processes. Neuro-Behcet, found in 10%-25% of Behcet patients, has been characterized as a vasculitis primarily affecting the brain stem. On magnetic resonance imaging, some cases demonstrate extension to the bilateral cerebral cortices and/or the spinal cord, often with a degree of mass effect. Content of this paper provides a case study, along with review of the literature regarding this disease entity, and proceeds to outline the appearance of neuro-Behcet on magnetic resonance spectroscopy. Conclusion In essence, a drop in the N-acetyl aspartate peak indicative of axonal loss in concert with elevations in lipid myoinositol and choline/creatine ratios (nonspecific markers of myelin breakdown) is found, indicating that a possible demyelinating process is complexed with the vasculitic pathology neuro-Behcet is traditionally ascribed to. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|