Anti-PGL-I seroepidemiology in leprosy cases: household contacts and school children from a hyperendemic municipality of the Brazilian Amazon
| Autor: | Denis Vieira Gomes Ferreira, Layana de Souza Guimarães, Claudio Guedes Salgado, R. A. Lima, Márcia Regina Neves Leão, Josafá Gonçalves Barreto |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Young Adult Seroepidemiologic Studies Leprosy Internal medicine Prevalence Humans Medicine Child Students Aged General Environmental Science Antigens Bacterial Family Characteristics business.industry Amazon rainforest Middle Aged medicine.disease Antibodies Bacterial Mycobacterium leprae Cross-Sectional Studies General Earth and Planetary Sciences Female Glycolipids business Brazil |
| Zdroj: | ResearcherID |
| ISSN: | 2162-8807 |
| Popis: | We investigated the prevalence of antibodies against PGL-I in people affected by leprosy (PAL) who were diagnosed and treated between 2004 and 2010, their household contacts (HC) and school children (SC) from a hyperendemic municipality in the Brazilian Amazon, and determined the prevalence of previously undiagnosed leprosy (PPUL) among both the HC and SC.We conducted a cross-sectional study involving 87 PAL, 302 HC and 188 SC. The subjects were clinically assessed, and their levels of anti-PGL-I antibodies were determined by ELISA. The subjects were also interviewed to determine their demographic and socio-economic characteristics.For PAL, a mean of 44 (SD = 21.8) months had passed since their initial diagnosis, and 34 (39%) of them remained seropositive. The level of anti-PGL-I antibodies was significantly higher in multibacillary (MB) than in paucibacillary (PB) cases (P0.05). Thirty-nine percent of HC were positive for anti-PGL-I, and we detected eight (2.6%) new cases among these individuals. One hundred and twenty-five SC (66.5%) were seropositive, and we detected nine (4.8%) new cases of leprosy (eight PB and one MB) in this group. When we visited the homes of SC affected by leprosy, 31 contacts were clinically examined, and three (10%) new cases were detected (one PB and two MB). The mean age of students with leprosy was 14.1 years (SD = 2.5; min = 10, max = 18).The seroepidemiology of anti-PGL-I and the PPUL among both HC and SC suggests that there are many active foci of infection and that Mycobacterium leprae is circulating among this population. |
| Databáze: | OpenAIRE |
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