Platelet-activating factor (PAF-acether) formation in neonatal intestinal mucosa and in cultured intestinal epithelial cells
| Autor: | Björn Weström, C. Gustafson, Lennart Franzén, Rune Sjödahl, C. Tagesson, Bengt Kald |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Colon
chemistry.chemical_element Inflammation Biology Calcium In Vitro Techniques Inflammatory bowel disease Epithelium Rats Sprague-Dawley chemistry.chemical_compound Intestinal mucosa Intestine Small medicine Animals Intestinal Mucosa Platelet Activating Factor Calcimycin Cells Cultured Platelet-activating factor respiratory system medicine.disease Molecular biology Small intestine Rats medicine.anatomical_structure chemistry Animals Newborn Cell culture Immunology lipids (amino acids peptides and proteins) Surgery medicine.symptom |
| Zdroj: | European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes. 24(6) |
| ISSN: | 0014-312X |
| Popis: | We report the presence of platelet-activating factor (PAF-acether; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in small-intestinal and colonic mucosa of neonatal rats. The PAF-acether content was higher in the colon than in the small intestine, and was lower in the small intestine of 30-day-old animals than in 14-day-old animals. We also report that cultured intestinal epithelial cells (INT 407) produce PAF-acether when stimulated with the calcium ionophore A23187, and that homogenized INT 407 cells can degrade PAF-acether with the formation of lysoPAF-acether. These findings suggest that intestinal epithelial cells are able to produce and metabolize PAF-acether, a potent mediator of inflammation. The authors propose that this might contribute to the pathophysiology of inflammatory bowel disease. |
| Databáze: | OpenAIRE |
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