New positive inotropic agents acting by phosphodiesterase inhibition or alpha1 adrenergic stimulation
| Autor: | Jens Scholz, Wilhelm Schmitz, H. Scholz, H. v. Der Leyen |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Inotrope
medicine.medical_specialty Cardiotonic Agents Adrenergic receptor Phosphodiesterase Inhibitors Stimulation Pharmacology Phosphatidylinositols Internal medicine Cyclic AMP medicine Animals Phosphoinositide Pathway business.industry Myocardium Cardiac muscle Phosphodiesterase medicine.disease Myocardial Contraction Endocrinology medicine.anatomical_structure Mechanism of action Heart failure Calcium medicine.symptom business Adrenergic alpha-Agonists |
| Zdroj: | Pharmacological Research. 21:329-337 |
| ISSN: | 1043-6618 |
| DOI: | 10.1016/1043-6618(89)90150-3 |
| Popis: | New knowledge and insight into cardiac muscle physiology and pharmacology together with the development of novel drugs may change the treatment of congestive heart failure in the future. This article reviews two newer inotropic mechanisms currently under investigation. It will place special emphasis on the mechanisms of action of selective cardiac phosphodiesterase inhibition and of alpha 1 -adrenoceptor mediated stimulation of the phosphoinositide pathway. |
| Databáze: | OpenAIRE |
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