VEGF-B inhibits hyperglycemia- and Macugen-induced retinal apoptosis
| Autor: | Xiangrong Ren, Liying Xing, Geng Tian, Xuri Li, Delong Huang, Qishan Chen, Zhiqin Gao, Anil Kumar, Zhimin Ye, Chen Zhao, Zhongshu Tang, Shasha Wang, Lijuan Huang, Wei Chen, Shuping Zhang, Jia Mi, Bin Wang, Xianglin Li, Rong Ju, Lixian Liu, Chunsik Lee, Lei Zheng |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Retinal Ganglion Cells
0301 basic medicine Vascular Endothelial Growth Factor B medicine.medical_specialty Apoptosis Pharmacology Biology Article Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound Retinal Diseases Neuropilin 1 medicine Animals Protein kinase B Multidisciplinary Retinal Diabetic retinopathy Aptamers Nucleotide Streptozotocin medicine.disease Rats Surgery Mice Inbred C57BL Vascular endothelial growth factor B Vascular endothelial growth factor Treatment Outcome 030104 developmental biology medicine.anatomical_structure Retinal ganglion cell chemistry medicine.drug |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Vascular endothelial growth factor B (VEGF-B) was discovered a long time ago. However, its role in hyperglycemia- and VEGF-A inhibition-induced retinal apoptosis remains unknown thus far. Yet, drugs that can block VEGF-B are being used to treat patients with diabetic retinopathy and other ocular neovascular diseases. It is therefore urgent to have a better understanding of the function of VEGF-B in these pathologies. Here, we report that both streptozotocin (STZ)-induced diabetes in rats and Macugen intravitreal injection in mice leads to retinal apoptosis in retinal ganglion cell and outer nuclear layers respectively. Importantly, VEGF-B treatment by intravitreal injection markedly reduced retinal apoptosis in both models. We further reveal that VEGF-B and its receptors, vascular endothelial growth factor 1 (VEGFR1) and neuropilin 1 (NP1), are abundantly expressed in rat retinae and choroids and are upregulated by high glucose with concomitant activation of Akt and Erk. These data highlight an important function of VEGF-B in protecting retinal cells from apoptosis induced by hyperglycemia and VEGF-A inhibition. VEGF-B may therefore have a therapeutic potential in treating various retinal degenerative diseases, and modulation of VEGF-B activity in the eye needs careful consideration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|