Removal of Alpha-Methyldopa (Aldomet) in Man by Dialysis
| Autor: | Billy K. Yeh, P. G. Dayton, William C. Waters |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Carbon Isotopes
medicine.medical_specialty business.industry medicine.medical_treatment Metabolite Urology Alpha methyldopa General Biochemistry Genetics and Molecular Biology Peritoneal dialysis chemistry.chemical_compound chemistry Renal Dialysis Hypertension medicine Humans In patient Methyldopa cardiovascular diseases Hemodialysis business Peritoneal Dialysis Dialysis Uremia |
| Zdroj: | Experimental Biology and Medicine. 135:840-843 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | SummaryDialytic removal of alpha-methyldopa (Aldomet) has been investigated in chronic uremic patients undergoing either hemodialysis or peritoneal dialysis, using 14C tracer techniques. A mean of 60% of the estimated absorbed radioactivity was recovered in the dialysate of 3 patients undergoing 4 hemodialyses; the mean relative dialysance of radioactivity from alpha-methyldopa and its products was 0.34. A similar amount of radioactivity was recovered in the dialysate of 2 patients undergoing peritoneal dialysis.The antihypertensive action of administered alpha-methyldopa and its major metabolite (a mono-O-sulfate conjugate) may be diminished by hemodialysis. This effect could contribute to the reemergence of hypertension occasionally observed in the postdialysis period in patients receiving alpha-methyldopa therapy. |
| Databáze: | OpenAIRE |
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