Comparison of gut microbiota in autism spectrum disorders and neurotypical boys in China: A case-control study
| Autor: | Qi Zhang, Liming Wang, Zhiyi Wang, Pengfei Xu, Fang Ye, Shuman Cao, Guangcai Liang, Zhitang Lv, Xinying Gao, Danni He |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
China QH301-705.5 Biomedical Engineering Gut flora 01 natural sciences Applied Microbiology and Biotechnology Article 03 medical and health sciences Structural Biology 010608 biotechnology Megasphaera mental disorders Genetics medicine Microbiome Biology (General) 030304 developmental biology 0303 health sciences Gut microbiome biology Akkermansia Autism spectrum disorders biology.organism_classification medicine.disease Autism Dialister Neurotypical TP248.13-248.65 Ruminococcaceae Biotechnology |
| Zdroj: | Synthetic and Systems Biotechnology Synthetic and Systems Biotechnology, Vol 6, Iss 2, Pp 120-126 (2021) |
| ISSN: | 2405-805X |
| Popis: | Background Autism spectrum disorders (ASDs) are a set of complex neurobiological disorders. Growing evidence has shown that the microbiota that resides in the gut can modulate brain development via the gut–brain axis. However, direct clinical evidence of the role of the microbiota–gut–brain axis in ASD is relatively limited. Methods A case-control study of 71 boys with ASD and 18 neurotypical controls was conducted at China-Japan Friendship Hospital. Demographic information and fecal samples were collected, and the gut microbiome was evaluated and compared by 16S ribosomal RNA gene sequencing and metagenomic sequencing. Results A higher abundance of operational taxonomic units (OTUs) based on fecal bacterial profiling was observed in the ASD group. Significantly different microbiome profiles were observed between the two groups. At the genus level, we observed a decrease in the relative abundance of Escherichia, Shigella, Veillonella, Akkermansia, Provindencia, Dialister, Bifidobacterium, Streptococcus, Ruminococcaceae UCG_002, Megasphaera, Eubacterium_coprostanol, Citrobacter, Ruminiclostridium_5, and Ruminiclostridium_6 in the ASD cohort, while Eisenbergiella, Klebsiella, Faecalibacterium, and Blautia were significantly increased. Ten bacterial strains were selected for clinical discrimination between those with ASD and the neurotypical controls. The highest AUC value of the model was 0.947. Conclusion Significant differences were observed in the composition of the gut microbiome between boys with ASD and neurotypical controls. These findings contribute to the knowledge of the alteration of the gut microbiome in ASD patients, which opens the possibility for early identification of this disease. |
| Databáze: | OpenAIRE |
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