Impaired renal concentrating ability in hypothyroid man
| Autor: | Ulrich F. Michael, Carlos A. Vaamonde, Mario J. Sebastianelli, James R. Oster, Liliana S. Vaamonde, Eugene L. Klingler, Solomon Papper |
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| Rok vydání: | 1976 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Natriuresis In Vitro Techniques Kidney Concentrating Ability Hypothyroidism Sodium excretion Internal medicine Myxedema medicine Humans Euthyroid Aged Reabsorption business.industry Osmolar Concentration Sodium Water Middle Aged medicine.disease Impaired renal concentrating ability Endocrinology Kidney Tubules Female business hormones hormone substitutes and hormone antagonists Glomerular Filtration Rate |
| Zdroj: | Nephron. 17(5) |
| ISSN: | 1660-8151 |
| Popis: | The renal concentrating ability was studied in ten patients with hypothyroidism and in 15 euthyroid controls. Solute-free water reabsorption was reduced in the patients with myxedema (4.2 +/- 0.3 ml/min: controls 5.8 +/- 0.6 ml/min; p less than 0.01). This defect was apparent at high rates of solute excretion, and was associated with enhanced excretion of sodium (p less than 0.01) despite a decreased filtered load (p less than 0.005). The myxedema patients had a modest reduction in maximal urine osmolality (p less than 0.04), which was entirely attributable to the lower values observed in younger patients. The results may be explained best by decreased sodium chloride reabsorption in the ascending limb of Henle's loop and/or diminished permeability of the distal nephron in myxedema. |
| Databáze: | OpenAIRE |
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