Laparoscopic liver resection of hepatocellular carcinoma located in unfavorable segments: a propensity score-matched analysis from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry
| Autor: | G.L. Grazi, Fausto Zamboni, Fulvio Calise, Giovanni Sgroi, Giorgio Rossi, Antonio Giuliani, G.B. Levi Sandri, S. Berti, Abdallah Slim, Antonio Floridi, Roberto Santambrogio, P. Mezzatesta, Felice Giuliante, Giulio Belli, Giovanni Vennarecci, Salvatore Gruttadauria, Vincenzo Mazzaferro, R. Dalla Valle, Alberto Brolese, Alessandro Ferrero, A. Coratti, Francesca Ratti, Nadia Russolillo, Andrea Ruzzenente, Giuseppe Maria Ettorre, A. Antonucci, Giuseppe Navarra, M. Iaria, L. Vincenti, P. Bonsignore, P. Maida, Ugo Boggi, G. Griseri, A. Parisi, Alfredo Guglielmi, Elio Jovine, Enrico Gringeri, Guido Torzilli, Umberto Cillo, Michele Colledan, F. Di Benedetto, Paolo Magistri, A. Frena, Fabio Ferla, Andrea Scotti, Matteo Virdis, A.D. Pinna, Luca Aldrighetti, L. De Carlis, Graziano Ceccarelli |
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| Přispěvatelé: | Sandri, Gbl, Ettorre, Gm, Aldrighetti, L, Cillo, U, Dalla Valle, R, Guglielmi, A, Mazzaferro, V, Ferrero, A, Di Benedetto, F, Gruttadauria, S, De Carlis, L, Vennarecci, G, Antonucci, A, Belli, G, Berti, S, Boggi, U, Bonsignore, P, Brolese, A, Calise, F, Ceccarelli, G, Colledan, M, Coratti, A, Ferla, F, Floridi, A, Frena, A, Giuliani, A, Giuliante, F, Grazi, Gl, Gringeri, E, Griseri, G, Iaria, M, Jovine, E, Paolo, M, Maida, P, Mezzatesta, P, Russolillo, N, Navarra, G, Parisi, A, Pinna, Ad, Ratti, F, Rossi, Ge, Ruzzenente, A, Santambrogio, R, Scotti, A, Sgroi, G, Slim, A, Torzilli, G, Vincenti, L, Virdis, M, Zamboni, F, Levi Sandri G.B., Ettorre G.M., Aldrighetti L., Cillo U., Dalla Valle R., Guglielmi A., Mazzaferro V., Ferrero A., Di Benedetto F., Gruttadauria S., De Carlis L., Vennarecci G., Antonucci A., Belli G., Berti S., Boggi U., Bonsignore P., Brolese A., Calise F., Ceccarelli G., Colledan M., Coratti A., Ferla F., Floridi A., Frena A., Giuliani A., Giuliante F., Grazi G.L., Gringeri E., Griseri G., Iaria M., Jovine E., Magistri P., Maida P., Mezzatesta P., Russolillo N., Navarra G., Parisi A., Pinna A.D., Ratti F., Rossi G.E., Ruzzenente A., Santambrogio R., Scotti A., Sgroi G., Slim A., Torzilli G., Vincenti L., Virdis M., Zamboni F., Levi Sandri, G, Ettorre, G, Grazi, G, Magistri, P, Pinna, A, Rossi, G |
| Rok vydání: | 2019 |
| Předmět: |
Laparoscopic surgery
Registrie Male Hepatocellular carcinoma medicine.medical_treatment Settore MED/18 - CHIRURGIA GENERALE Laparoscopic HCC Posterior segment Hepatocellular carcinoma IGoMILS Child B Laparoscopic liver resection 0302 clinical medicine Postoperative Complications Prospective Studies Registries Laparoscopy Prospective cohort study medicine.diagnostic_test Laparoscopic HCC Liver Neoplasms Margins of Excision IGoMILS Middle Aged Laparoscopic liver resection Child B Italy Liver Neoplasm 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Female Human medicine.medical_specialty Carcinoma Hepatocellular Matched-Pair Analysis Operative Time NO 03 medical and health sciences medicine Humans Hepatectomy Blood Transfusion Matched-Pair Analysi Posterior segment Aged Postoperative Care LS7_4 Surgery business.industry Carcinoma Hepatocellular Perioperative medicine.disease digestive system diseases Child B Hepatocellular carcinoma IGoMILS Laparoscopic HCC Laparoscopic liver resection Posterior segment Aged Blood Transfusion Carcinoma Hepatocellular Female Humans Italy Liver Neoplasms Male Margins of Excision Matched-Pair Analysis Middle Aged Operative Time Postoperative Care Postoperative Complications Prospective Studies Registries Hepatectomy Laparoscopy Prospective Studie Propensity score matching Postoperative Complication business Abdominal surgery |
| Popis: | Objective: Laparoscopic liver resection (LLR) for Hepatocellular Carcinoma (HCC) is one of the most important indications for the minimally invasive approach. Our study aims to analyze the experience of the Italian Group of Minimally Invasive Liver Surgery with laparoscopic surgical treatment of HCC, with a focus on tumor location and how it affects morbidity and mortality. Methods: 38 centers participated in this study; 372 cases of LLR for HCC were prospectively enrolled. Patients were divided into two groups according to the HCC nodule location. Group 1 favorable location and group 2 unfavorable location. Perioperative outcomes were compared between the two groups before and after a propensity score match (PS) 1:1. Results: Before PS in group 2 surgical time was longer; conversion rate was higher; postoperative transfusion and comprehensive complication index were also higher. PS was performed with a cohort of 298 patients (from 18 centers), with 66 and 232 patients with HCC in unfavorable and favorable locations, respectively. After PS matching, 62 patients from group 1 and group 2 each were compared. Operative and postoperative course were similar in patients with HCC in favorable and unfavorable LLR locations. Surgical margins were found to be identical before and after PS. Conclusions: These results show that LLR in patients with HCC can be safely performed in all segments because of the extensive experience of all surgeons from multiple centers in performing traditional open liver surgery as well as laparoscopic surgery. |
| Databáze: | OpenAIRE |
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