Clinical outcome of adjuvant radiotherapy for squamous cell carcinoma of the breast; a multicenter retrospective cohort study

Autor: Mami Ogita, Hideomi Yamashita, Kenji Tokumasu, Kenshiro Shiraishi, Jiro Kawamori, Naomi Nakajima, Katsuyuki Karasawa, Ta-Chen Chang, Keiichi Nakagawa
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Oncology
PMRT
post-mastectomy radiotherapy (PMRT)
ER
estrogen receptor
Lymphovascular invasion
medicine.medical_treatment
SCC
squamous cell carcinoma
AC
doxorubicin and cyclophosphamide
Cohort Studies
0302 clinical medicine
Breast cancer
Risk Factors
Recurrence
Squamous cell carcinoma
HER2
human epidermal growth factor receptor 2
030212 general & internal medicine
Lymph node
Aged
80 and over
CMF
cyclophosphamide
methotrexate
and 5-fluorouracil
BCSS
breast cancer-specific survival
Incidence (epidemiology)
General Medicine
Middle Aged
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.anatomical_structure
RFi
recurrence-free interval
030220 oncology & carcinogenesis
Lymphatic Metastasis
FEC
epirubicin and cyclophosphamide
Carcinoma
Squamous Cell
Female
Original Article
IDC
invasive ductal carcinoma
Mastectomy
PARP
poly (ADP-ribose) polymerase
Adult
medicine.medical_specialty
FAP
5-FU
cisplatin and doxorubicin
RNI
regional nodal irradiation
Breast Neoplasms
UICC
the Union for International Cancer Control
CTCAE
the Common Terminology Criteria for Adverse Events
lcsh:RC254-282
OS
overall survival
03 medical and health sciences
Internal medicine
medicine
Humans
EBCTCG
the Early Breast Cancer Trialists’ Collaborative Group
Aged
Retrospective Studies
Radiotherapy
business.industry
Retrospective cohort study
medicine.disease
SEER
the Surveillance
Epidemiology and End Results
Survival Analysis
EGFR
epidermal growth factor receptor
Radiation therapy
PgR
progesterone receptor
Surgery
Radiotherapy
Adjuvant
Neoplasm Recurrence
Local
business
Rare disease
Zdroj: Breast, Vol 52, Iss, Pp 88-94 (2020)
The Breast : official journal of the European Society of Mastology
ISSN: 1532-3080
Popis: Background Because primary squamous cell carcinoma (SCC) of the breast is a rare disease, the standard therapy has not been established. We examined the clinical outcomes of postoperative adjuvant radiotherapy for breast SCC. Material and methods We conducted a multicenter retrospective cohort study. Patients diagnosed with primary breast SCC who received adjuvant radiotherapy as part of their primary definitive treatment were included. Overall survival (OS), breast cancer-specific survival (BCSS), and recurrence-free interval (RFi) were evaluated. Results Between January 2002 and December 2017, 25 breast SCC patients received adjuvant radiotherapy as a primary treatment were included. Median follow-up time was 43.5 months. Three (12%), fifteen (60%) and seven (28%) patients had clinical stage I, II and III disease, respectively. Fourteen patients underwent breast-conserving surgery and subsequent adjuvant radiotherapy. Eleven patients underwent mastectomy and post-mastectomy radiotherapy. Ten patients received regional lymph node irradiation. Nine (36%) patients had disease recurrence. The first site of recurrence was locoregional in five, but distant metastasis arose in one. Concurrent local and distant metastasis were seen in two. Six cases of local recurrence occurred within the irradiated site. Seven patients died, and six of the deaths were due to breast cancer. Five-year OS, BCSS, and Rfi were 69%, 70%, and 63%, respectively. In multivariate analysis, age and lymphatic invasion were associated with increased risk of recurrence. Conclusion Breast SCC has a high incidence of locoregional recurrence and poor prognosis. Age and lymphatic invasion are significant risk factors for recurrence.
Highlights • Clinical outcome of adjuvant radiotherapy for SCC of the breast was evaluated. • Breast SCC had poor prognosis and a high incidence of locoregional recurrence. • In-field recurrence following radiotherapy occurred frequently. • Age and lymphatic invasion were significantly associated with increased risk of recurrence.
Databáze: OpenAIRE
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