OLIG2 is differentially expressed in pediatric astrocytic and in ependymal neoplasms
| Autor: | Scott R. VandenBerg, David H. Rowitch, Jose Otero |
|---|---|
| Přispěvatelé: | Rowitch, David [0000-0002-0079-0060], Apollo - University of Cambridge Repository |
| Rok vydání: | 2011 |
| Předmět: |
Ependymoma
Male Cancer Research Pathology medicine.medical_specialty Adolescent OLIG2 Oncology and Carcinogenesis Clinical Neurology Nerve Tissue Proteins Biology Astrocytoma 03 medical and health sciences 0302 clinical medicine Glioma medicine Basic Helix-Loop-Helix Transcription Factors Humans Oligodendroglial Tumor Pediatric ependymoma Pediatric astrocytoma Cell Lineage Pilocytic astrocytoma Oncology & Carcinogenesis Pediatric glioma Child neoplasms 030304 developmental biology 0303 health sciences Laboratory Investigation - Human/Animal Tissue Neurosciences Oligodendrocyte Transcription Factor 2 medicine.disease Immunohistochemistry nervous system diseases Neurology Oncology Tissue Array Analysis Female Neurology (clinical) 030217 neurology & neurosurgery |
| Zdroj: | Journal of neuro-oncology, vol 104, iss 2 Journal of Neuro-Oncology |
| Popis: | The bHLH transcription factor, OLIG2, is universally expressed in adult human gliomas and, as a major factor in the development of oligodendrocytes, is expressed at the highest levels in low-grade oligodendroglial tumors. In addition, it is functionally required for the formation of high-grade astrocytomas in a genetically relevant murine model. The pediatric gliomas have genomic profiles that are different from the corresponding adult tumors and accordingly, the expression of OLIG2 in non-oligodendroglial pediatric gliomas is not well documented within specific tumor types. In the current study, the pattern of OLIG2 expression in a spectrum of 90 non-oligodendroglial pediatric gliomas varied from very low levels in the ependymomas (cellular and tanycytic) to high levels in pilocytic astrocytoma, and in the diffuse-type astrocytic tumors (WHO grades II–IV). With dual-labeling, glioblastoma had the highest percentage of OLIG2 expressing cells that were also Ki-67 positive (mean = 16.3%) whereas pilocytic astrocytoma WHO grade I and astrocytoma WHO grade II had the lowest (0.9 and 1%, respectively); most of the Ki-67 positive cells in the diffuse-type astrocytomas (WHO grade II–III) were also OLIG2 positive (92–94%). In contrast to the various types of pediatric astrocytic tumors, all ependymomas WHO grade II, regardless of site of origin, showed at most minimal OLIG2 expression, suggesting that OLIG2 function in pediatric gliomas is cell lineage dependent. Electronic supplementary material The online version of this article (doi:10.1007/s11060-010-0509-x) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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