Relay tricyclic Pd(ii)/Ag(i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR
| Autor: | Vijai K. Agnihotri, Ramdas S. Pathare, Devesh M. Sawant, Shahnawaz Khan, Sourav Kalra, Shivani Sharma, Antim K. Maurya, Gaurav Joshi, Ramesh K. Metre, Raj Kumar, Sukanya Sukanya, Ram T. Pardasani |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
Four component 010405 organic chemistry Nitrene Isocyanide Metals and Alloys General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials law.invention chemistry.chemical_compound Chemical bond chemistry Relay law Materials Chemistry Ceramics and Composites Bimetallic strip Tricyclic |
| Zdroj: | Chemical communications (Cambridge, England). 54(82) |
| ISSN: | 1364-548X |
| Popis: | Synthesis of pyrazolo[1,5-c]quinazolines from four easily available precursors is presented through a one-pot tricyclic Pd(ii)/Ag(i) relay catalysis. The bimetallic relay cascade forges five new chemical bonds by concatenating six discrete chemical steps. The relay catalysis enables four-component assembly of pyrazolo[1,5-c]quinazolines that selectively inhibit EGFR, exhibit apoptosis through the ROS-induced mitochondrial-mediated pathway, and arrest the cell cycle at the G1 phase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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