Validation of the simplified Animal Naming Test as primary screening tool for the diagnosis of covert hepatic encephalopathy
| Autor: | Jens U. Marquardt, M Nguyen-Tat, Tim Zimmermann, Martin F. Sprinzl, Peter R. Galle, Yvonne Huber, Christian Labenz, Gerrit Toenges, Michael Nagel, Marcus-Alexander Wörns, Jörn M. Schattenberg, Larissa Beul |
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| Rok vydání: | 2019 |
| Předmět: |
Liver Cirrhosis
Male Pediatrics medicine.medical_specialty Psychometrics Flicker fusion threshold Neuropsychological Tests 030204 cardiovascular system & hematology Risk Assessment Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Reference Values Germany Internal Medicine medicine Animals Humans In patient Prospective Studies 030212 general & internal medicine Hepatic encephalopathy Aged business.industry Middle Aged medicine.disease Test (assessment) Clinical Practice ROC Curve Covert Case-Control Studies Hepatic Encephalopathy Cohort Female business Primary screening |
| Zdroj: | European Journal of Internal Medicine. 60:96-100 |
| ISSN: | 0953-6205 |
| Popis: | Diagnosis of covert hepatic encephalopathy (CHE) is time consuming in clinical practice. Recently, a new diagnostic tool - the simplified Animal Naming Test (S-ANT1) - was presented with promising results in an Italian cohort. The aim of the present study was to validate S-ANT1 in a cohort of cirrhotic patients from a German tertiary referral centre.143 cirrhotic patients and 37 healthy controls were enrolled. Hepatic encephalopathy (HE) grade 1 (HE1) was clinically diagnosed according to the West-Haven Criteria. Critical flicker frequency and Psychometric Hepatic Encephalopathy Score were used to detect minimal HE (MHE). All participants were additionally examined by S-ANT1.58 (40.6%) patients presented with CHE (40 MHE, 18 HE1). S-ANT1 was lowest in patients with HE1, followed by patients with MHE, patients without CHE, and healthy controls, respectively (each p 0.05). Naming20 animals discriminated best between patients with and without CHE in ROC analysis (with Youden's index). With a cut-off value of ≥23 mentioned animal names further testing for CHE could be avoided in 38.5% of patients with a negative predictive value of 84%.S-ANT1 may become an important first screening tool for the assessment of CHE in clinical practice. |
| Databáze: | OpenAIRE |
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