Virus-Induced Leukopenia: Colorado Tick Fever as a Human Model
| Autor: | Maureen A. Entringer, Richard D. Andersen, William A. Robinson |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Colorado Tick Fever Biology Granulopoiesis Peripheral blood mononuclear cell Virus Colony-Stimulating Factors Immunopathology Leukocytes medicine Humans Immunology and Allergy Child Leukopenia Colorado tick fever Middle Aged medicine.disease Colony-stimulating factor Reoviridae Infections Endotoxins Blood Infectious Diseases Child Preschool Immunology Female Viral disease medicine.symptom |
| Zdroj: | Journal of Infectious Diseases. 151:449-453 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/151.3.449 |
| Popis: | Eight patients with Colorado tick fever were studied to determine whether alterations in the production of granulopoietic stimulatory or inhibitory factors (or both) could be found in association with the leukopenic state of the disease. The studies demonstrate that in the patients with Colorado tick fever the mononuclear cell production of colony-stimulating factor is decreased and that there is an increase in circulating inhibitory factors in the serum of such patients. The depressed mononuclear cell colonystimulating activity does not appear to be reversible by addition of either endotoxin or normal human serum. Characterization of these serum inhibitory factors may facilitate understanding of leukopenia in human disease. Leukopenia, particularly granulocytopenia, occurs in association with a large number of viral infections. Interest in viras-related and other leukopenic states has grown recently because of increased understanding of the factors regulating granulopoiesis and the possible relevance of these factors to the pathophysiologic events occurring in human im |
| Databáze: | OpenAIRE |
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