Correlation between estimated plasma remnant-like particle cholesterol and vegetable fat intake in Uku town, Japan
| Autor: | Ako Fukami, Sachiko Nakamura, Akiko Sakaue, Tatsuyuki Kakuma, Nagisa Morikawa, Yoshihiro Fukumoto, Maki Yamamoto, Yume Nohara, Mika Enomoto, Hisashi Adachi |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Apolipoprotein E Epidemiology Lipoproteins Remnant-like particle cholesterol Correlation chemistry.chemical_compound Animal science Japan Vegetables medicine Humans Triglycerides Aged Aged 80 and over medicine.diagnostic_test Receiver operating characteristic Cholesterol Vegetable fat intake Public Health Environmental and Occupational Health Vegetable fat General Medicine Middle Aged Stepwise regression Dietary Fats Lipids Lipid profile chemistry Female Research Article |
| Zdroj: | Environmental Health and Preventive Medicine |
| ISSN: | 1347-4715 1342-078X |
| DOI: | 10.1186/s12199-021-01005-4 |
| Popis: | Background Remnant-like particle cholesterol (RLP-C) is highly atherogenic, which is associated with atherosclerosis. However, RLP-C has not been routinely measured in the clinical practice. We estimated RLP-C levels using conventional lipid profiles and examined the association between estimated RLP-C and related factors including nutrient intake. Methods This study was performed in Uku town, Nagasaki prefecture, Japan in 2019. A total of 225 subjects were enrolled and directly measured RLP-C levels. Estimated RLP-C levels were defined as the following formula [total cholesterol − (LDL-cholesterol) − (HDL-cholesterol)]. Multivariate analyses were used to assess the relationship between estimated RLP-C and atherogenic factors. We calculated cut-off values on dichotomized RLP-C ( Results The mean values of directly measured RLP-C levels and estimated RLP-C were 4.0 mg/dL and 16.4 mg/dL, respectively. In the multiple stepwise linear regression analysis, directly measured and estimated RLP-C levels were independently and commonly associated with apolipoprotein E, triglycerides, and vegetable fat intake (inversely). Using ROC curves, we found the cut-off value of estimated RLP-C was 22.0 mg/dL. Conclusion We demonstrated that the estimated RLP-C levels using conventional lipid profiles may substitute for directly measured RLP-C and these levels were independently and inversely associated with vegetable fat intake in the community-dwelling Japanese population. |
| Databáze: | OpenAIRE |
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