Prognostic value of [18F]FDG-PET/CT in multiple myeloma patients before and after allogeneic hematopoietic cell transplantation

Autor: Götz Ulrich Grigoleit, Katharina Kneer, Constantin Lapa, Antje Stolzenburg, Donald Bunjes, Hermann Einsele, Andreas K. Buck, Samuel Samnick, Stefan Knop, Ambros J. Beer, Jan-Stefan Schmid, Susanne Hofmann, Martin Speer, Katharina Lückerath
Rok vydání: 2018
Předmět:
Zdroj: European Journal of Nuclear Medicine and Molecular Imaging. 45:1694-1704
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-018-3997-0
Popis: Despite improved treatment options, multiple myeloma (MM) remains an incurable disease. The aim of this study was to investigate the prognostic value of positron emission tomography/computed tomography (PET/CT) using 18F-2’-deoxy-2’-fluorodeoxyglucose ([18F]FDG) in MM patients shortly before and ~100 days after allogeneic hematopoietic cell transplantation (allo-HCT). In this retrospective analysis, we evaluated [18F]FDG-PET/CT-scans of 45 heavily pre-treated MM patients before and 27 patients after scheduled allo-HCT. All scans were qualitatively and semi-quantitatively assessed for the presence of active disease. Serological response was recorded according to International Myeloma Working Group (IMWG) criteria. Progression-free (PFS) and overall survival (OS) were correlated with different PET/CT-derived parameters, such as presence, number and maximum standardized uptake value (SUVmax) of focal myeloma lesions. The impact of extramedullary disease on patient outcome was also assessed. PET/CT negativity -prior to or following allo-HCT- was a favorable prognostic factor for progression-free and overall survival (both, PFS and OS: pre-HSCT p 6.5) revealed a significantly shortened survival compared to patients with a lower SUVmax ( 3) of focal lesions (pre-HCT: both PFS and OS: p
Databáze: OpenAIRE
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