Down-regulation of c-FLIP increases reactive oxygen species, induces phosphorylation of serine/threonine kinase Akt, and impairs motility of cancer cells
| Autor: | Hae-Yeong Kim, Eunsook Shim, Yun Sil Lee, Dooil Jeoung |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
CASP8 and FADD-Like Apoptosis Regulating Protein
Motility Down-Regulation Bioengineering Biology Protein Serine-Threonine Kinases Applied Microbiology and Biotechnology Serine Cell Movement Humans Phosphorylation Protein kinase B Serine/threonine-specific protein kinase chemistry.chemical_classification Reactive oxygen species Protein-Serine-Threonine Kinases Kinase General Medicine Molecular biology Cell biology Oncogene Protein v-akt chemistry Reactive Oxygen Species Biotechnology HeLa Cells |
| Zdroj: | Biotechnology letters. 29(1) |
| ISSN: | 1573-6776 |
| Popis: | The role of c-FLIP in cell motility was investigated using RNA interference. Down-regulation of c-FLIP increased amounts of reactive oxygen species (ROS), while over-expression of c-FLIP produced opposite effect. ROS induced phosphorylation of Akt and impaired cell motility. |
| Databáze: | OpenAIRE |
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