Revisiting Cardiac Cellular Composition

Autor: Anjana Chandran, Malina J. Ivey, Lina Wang, Alexei Ilinykh, Nadia Rosenthal, Alexander R. Pinto, Komal Arora, Jill T. Kuwabara, Michelle L D'Antoni, Michelle D. Tallquist, Ryan J. Debuque
Rok vydání: 2016
Předmět:
Zdroj: Circulation Research. 118:400-409
ISSN: 1524-4571
0009-7330
Popis: Rationale: Accurate knowledge of the cellular composition of the heart is essential to fully understand the changes that occur during pathogenesis and to devise strategies for tissue engineering and regeneration. Objective: To examine the relative frequency of cardiac endothelial cells, hematopoietic-derived cells, and fibroblasts in the mouse and human heart. Methods and Results: Using a combination of genetic tools and cellular markers, we examined the occurrence of the most prominent cell types in the adult mouse heart. Immunohistochemistry revealed that endothelial cells constitute >60%, hematopoietic-derived cells 5% to 10%, and fibroblasts Conclusions: This new perspective on the abundance of different cell types in the heart demonstrates that fibroblasts comprise a relatively minor population. By contrast, endothelial cells constitute the majority of noncardiomyocytes and are likely to play a greater role in physiological function and response to injury than previously appreciated.
Databáze: OpenAIRE
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