Utility of QuantiFERON®-TB gold In-Tube test compared with tuberculin skin test in diagnosing tuberculosis in Indian children with malnutrition
| Autor: | Deepthi Boddu, Anila Chacko, Visali Jeyaseelan, Joy Sarojini Michael, Valsan Philip Verghese |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Pediatrics medicine.medical_specialty Tuberculosis children with malnutrition Concordance 030106 microbiology Immunology lcsh:QR1-502 Tuberculin tuberculin skin test Microbiology lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Tuberculosis diagnosis Immunology and Allergy Medicine 030212 general & internal medicine Prospective cohort study General Immunology and Microbiology business.industry Incidence (epidemiology) quantiferon-tb gold in-tube test Skin test medicine.disease bacterial infections and mycoses Malnutrition Infectious Diseases tuberculosis diagnosis business |
| Zdroj: | Indian Journal of Medical Microbiology, Vol 37, Iss 3, Pp 433-437 (2019) |
| ISSN: | 1998-3646 0255-0857 |
| Popis: | This prospective cohort study was conducted to compare the accuracy of QuantiFERON®-TB (QFT) Gold In-Tube test and tuberculin skin test (TST) in diagnosing tuberculosis (TB) in predominantly bacille Calmette-Guerin-vaccinated children with a high incidence of malnutrition. The sensitivity of the QFT versus the TST was 69.6% versus 52.9% for WHO-defined TB, with specificity of 86% versus 78.3%, respectively. The concordance of the TST and QFT was 79% overall (κ = 0.430), 62.5% in those with WHO-defined TB and 85.7% in those without TB. Majority of the QFT+/TST - discordance was seen in children with TB, whereas majority of the TST+/QFT - discordance was seen in those without TB. The TST was more likely to be negative in children with moderate-to-severe malnutrition (P = 0.003) compared to the QFT, which was more likely to be positive in younger children. The significantly better performance of the QFT in malnourished children and those at younger ages supports its use for TB diagnosis in these subpopulations. |
| Databáze: | OpenAIRE |
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