Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Autor:	Pamela Sklar, Paul Lichtenstein, Carlos Ferreira, Derek W. Morris, Douglas M. Ruderfer, Nigel Williams, Lyudmila Georgieva, Alan W Maclean, Emma M. Quinn, Srinivasa Thirumalai, Jacob Lawrence, Peter M. Visscher, Andrew McQuillin, António Macedo, Christina M. Hultman, Elaine Kenny, Kevin A. McGhee, George Kirov, Emma Flordal Thelander, Ayman H. Fanous, Walter J. Muir, Stacey Gabriel, Michael Conlon O'Donovan, Finny G Kuruvilla, Aiden Corvin, Edward M. Scolnick, Colm O'Dushlaine, Khalid Choudhury, Patrick Sullivan, Frank A. Middleton, Kimberly Chambert, Nicholas Walker, Christopher P. Morley, Patrick F. Sullivan, Michael Gill, Célia Barreto Carvalho, Manuel A. R. Ferreira, Susmita Datta, Robert Krasucki, M. Helena Azevedo, Soh Leh Kuan, Jennifer L. Moran, Stuart MacGregor, Draga Toncheva, P. Malloy, Douglas Blackwood, Shaun Purcell, Jonathan Pimm, Michael John Owen, Peter Holmans, David V. Conti, Gillian Fraser, Vinay Puri, Naomi R. Wray, Andrew Kirby, Margaret Van Beck, Digby Quested, Kristin G. Ardlie, Ben S. Pickard, Caroline Crombie, Vihra Milanova, Carlos N. Pato, Nicholas John Craddock, Jennifer Stone, Nadine Norton, Mark J. Daly, James A. Knowles, Hugh Gurling, David St Clair, Hywel Williams, Michele T. Pato, Helena Medeiros, Nicholas Bass, Ivan Nikolov
Rok vydání:	2009
Předmět:	Male Multifactorial Inheritance Bipolar Disorder Epigenetics of schizophrenia Genome-wide association study Biology Polymorphism Single Nucleotide Article Major Histocompatibility Complex Gene Frequency mental disorders medicine Humans Genetic Predisposition to Disease ANK3 Bipolar disorder Alleles Psychiatric genetics Genetics Multidisciplinary Models Genetic Genome Human Genetic Variation Genome Scans medicine.disease Psychiatric Disorder Europe Schizophrenia Case-Control Studies biology.protein Female Zinc finger protein 804A Genome-Wide Association Study Clinical psychology
Zdroj:	Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação instacron:RCAAP
ISSN:	1476-4687 0028-0836
DOI:	10.1038/nature08185
Popis:	Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with heritability estimated at up to 80%. We performed a genome-wide association study of 3,322 European individuals with schizophrenia and 3,587 controls. Here we show, using two analytic approaches, the extent to which common genetic variation underlies the risk of schizophrenia. First, we implicate the major histocompatibility complex. Second, we provide molecular genetic evidence for a substantial polygenic component to the risk of schizophrenia involving thousands of common alleles of very small effect. We show that this component also contributes to the risk of bipolar disorder, but not to several non-psychiatric diseases. info:eu-repo/semantics/publishedVersion
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c23ae7916a5645b581500ab2b14bce https://doi.org/10.1038/nature08185 Zobrazit plný text záznamu Plný text ve formátu PDF