Regional variations of vasomotion to G-protein coupled receptor agonists following heat stress in rats
| Autor: | Cang-Bao Xu, Lei Cao, Zhao Ma, Jie Li, Kun-Lun Chen, Yong-Xiao Cao |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Calcitonin Gene-Related Peptide Pharmaceutical Science Vasodilation Vasomotion In Vitro Techniques Calcitonin gene-related peptide Heat Stress Disorders Muscle Smooth Vascular Receptors G-Protein-Coupled Rats Sprague-Dawley Renal Artery Internal medicine medicine Animals Receptor Mesenteric arteries 5-HT receptor G protein-coupled receptor Pharmacology Neurotransmitter Agents Receptors Endothelin Chemistry Osmolar Concentration Arteries Mesenteric Arteries Rats Serotonin Receptor Agonists Femoral Artery medicine.anatomical_structure Endocrinology Organ Specificity Vasoconstriction cardiovascular system Endothelin receptor Adrenergic alpha-Agonists |
| Zdroj: | Journal of Pharmacy and Pharmacology. 62:315-322 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1211/jpp.62.03.0005 |
| Popis: | Objectives This study was designed to compare vascular contractile and relaxing responses to G-protein coupled receptor agonists among the different regions of arteries following heat stress in rats. Methods Heat exposure was performed by increasing the internal temperature of the rats to 42°C for 15 min. After heat stress for 48 h, a myograph system was used to monitor the contractile responses in rat renal, femoral and mesenteric arteries to agonists of endothelin type B (ETB) receptor, endothelin type A (ETA) receptor, serotonin receptor and α-adrenoceptor, respectively. In addition, calcitonin gene-related peptide (CGRP)-induced vasodilation was studied. Key findings The results showed that heat stress induced decreased contractions mediated by α-adrenoceptors and serotonin receptors (at lower concentration), while it increased contraction mediated by endothelin ETB receptors and enhanced relaxation mediated by CGRP receptors in the renal artery. Heat stress increased contractions mediated by endothelin ETB receptors, endothelin ETA receptors and α-adrenoceptors in the femoral artery. In the mesenteric artery, heat stress increased contractions mediated by endothelin ETB and serotonin receptors and relaxation mediated by CGRP receptors. Conclusions The vasomotor responses to the G-protein coupled receptor agonists with altered vascular contractions and relaxations were different in rat renal, femoral and mesenteric arteries after heat stress. This might have contributed to the redistribution of blood flow and aids understanding of the preconditioning phenomenon. |
| Databáze: | OpenAIRE |
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