A sex difference in the composition of the rodent postsynaptic density
| Autor: | Sumantra Chattarji, Mary B. Kennedy, Peter C. Kind, Shinjini Basu, Anthony Preza, Sally M. Till, Tara L Mastro |
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| Rok vydání: | 2019 |
| Předmět: |
Scaffold protein
0303 health sciences Rodent biology Chemistry musculoskeletal neural and ocular physiology PDZ domain Glutamate receptor Transmembrane protein Cell biology Loss of heterozygosity 03 medical and health sciences 0302 clinical medicine nervous system biology.animal mental disorders Postsynaptic density psychological phenomena and processes 030217 neurology & neurosurgery 030304 developmental biology |
| DOI: | 10.1101/802538 |
| Popis: | SynGAP is a postsynaptic density (PSD) protein that binds to PDZ domains of the scaffold protein PSD-95. We previously reported that heterozygous deletion of synGAP in mice is correlated with increased steady-state levels of other key PSD proteins that bind PSD-95, although the level of PSD-95 remains constant (Walkup et al., 2016). For example, the ratio to PSD-95 of Transmembrane AMPA-Receptor-associated Proteins (TARPs), which mediate binding of AMPA-type glutamate receptors to PSD-95, was increased in young synGAP+/- mice. Here we show that a highly significant increase in TARP in the PSDs of young synGAP+/- rodents is present only in females and not in males. The data reveal a sex difference in the adaptation of the PSD scaffold to synGAP heterozygosity. |
| Databáze: | OpenAIRE |
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