Factors associated with changes in volumetric bone mineral density and cortical area in men with ankylosing spondylitis : a 5-year prospective study using HRpQCT
| Autor: | Helena Forsblad-d'Elia, M. Hedberg, L. T. H. Jacobsson, Anna Deminger, Mattias Lorentzon, Hans Carlsten, Eva Klingberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
high-resolution peripheral quantitative computed tomography medicine.medical_specialty Bone density Endocrinology Diabetes and Metabolism Urology Orthopaedics Absorptiometry Photon Bone Density Cortical Bone medicine Bone mineral density Humans Spondylitis Ankylosing Prospective Studies Tibia Quantitative computed tomography Prospective cohort study Bone mineral DXA Ankylosing spondylitis medicine.diagnostic_test business.industry medicine.disease Publisher Correction radiology Radius medicine.anatomical_structure other diseases related to bone (ankylosing spondylitis) Orthopedic surgery Ortopedi Cortical bone Original Article sense organs business |
| Zdroj: | Osteoporosis International |
| Popis: | Summary: Patients with ankylosing spondylitis (AS) have impaired volumetric bone mineral density (vBMD) assessed with high-resolution peripheral computed tomography (HRpQCT). This first longitudinal HRpQCT study in AS shows that cortical and trabecular vBMD decreased at tibia and that signs of inflammation were associated with cortical bone loss at tibia and radius. Introduction: Patients with ankylosing spondylitis (AS) have reduced volumetric bone mineral density (vBMD) in the peripheral skeleton assessed with high-resolution peripheral quantitative computed tomography (HRpQCT). The aims were to investigate longitudinal changes in vBMD, cortical area, and microarchitecture and to assess factors associated with changes in vBMD and cortical area in men with AS. Methods: HRpQCT of radius and tibia was performed in 54 men with AS at baseline and after 5 years. Univariate and multivariable linear regression analyses were used. Results: At tibia, there were significant decreases exceeding least significant changes (LSC) in cortical and trabecular vBMD, mean (SD) percent change −1.0 (1.9) and −2.7 (5.0) respectively (pErrata: Deminger, A., Klingberg, E., Lorentzon, M. et al. Correction to: Factors associated with changes in volumetric bone mineral density and cortical area in men with ankylosing spondylitis: a 5-year prospective study using HRpQCT.. Osteoporos Int 32, 2601 (2021). DOI: 10.1007/s00198-021-06156-2 |
| Databáze: | OpenAIRE |
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